I started getting into InkScape recently, but struggled to get it running well on a multi-monitor set up of OSX Mavericks.
First up: Install XQuartz: http://xquartz.macosforge.org/landing/
Then: When you run Inscape for the first time, you'll be asked where X11 is?
Select Browse, then select to /Applications/Utilities/XQuartz.app
If done correctly, Inscape will launch, but fill up the incorrect screen.
So click on XQuartz in the dock. Go to it's preferences from the menu bar, and make sure Full-screen mode is enabled.
To change which monitor Inscape will be rendered on, go to the Dock, right click on XQuartz > options > select which Desktop it should be displayed on.